Table 2.
Effect of pregnancy on mRNA expression of key bile acid homeostasis genes in the terminal ileum
| NC |
CA |
OCA |
CA + OCA |
|||||
|---|---|---|---|---|---|---|---|---|
| NP | P | NP | P | NP | P | NP | P | |
| Shp | 3.17 ± 1.96 | 3.93 ± 0.36 | 229.70 ± 57.30 | 76.18 ± 14.53* | 670.4 ± 211.6 | 322.50 ± 80.76 | 398.90 ± 73.87 | 167.70 ± 36.85* |
| Fgfr15 | 1.47 ± 0.57 | 0.27 ± 0.14 | 4.29 ± 0.27 | 2.23 ± 0.40* | 2.88 ± 0.55 | 2.08 ± 0.64 | 4.10 ± 0.62 | 3.20 ± 0.66 |
Data are presented as means ± SE; n = 3–6 mice. CA, cholic acid; NC, normal chow diet; NP, nonpregnant; OCA, obeticholic acid; P, pregnant. Relative mRNA expression of target genes in NP and P females fed the same diet.
*
P ≤ 0.05 vs. NP females fed the same diet.