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Exemplary intestinal epithelial lineage-restricted transcription factors
| Transcription Factor |
|---|
| Expressed in all or most epithelial cells |
| Hnf4a |
| Hnf4g |
| Cdx2 |
| Gata4 |
| Gata6 |
| Enriched in resting and regenerating ISCs |
| Ascl2 |
| Enriched in enterocytes |
| Hes1 |
| Klf5 (enriched in crypt cells, including ISCs) |
| Enriched in secretory-fated cells |
| Atoh1 |
| Spdef |
| Gfi1 |
| Neurog3(enriched in endocrine cells) |
| Neurod1(enriched in endocrine cells) |
| Klf4 (enriched in goblet cells) |
ISC, intestinal stem cells.
