TABLE 2.

Cox regression analysis of mRNASig and OS of ccRCC in the training cohort.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	P	HR (95% CI)	P
Age	1.08 (1.01–1.05)	0.002	1.04 (1.01–1.06)	0.005
T stage
T1	Ref
T2	1.53 (0.74–3.14)	0.2
T3	2.7 (1.61–4.45)	<0.001
T4	9.79 (3.70–25.89)	<0.001
N Stage
N0	Ref
N1	5.72 (2.42–13.52)	<0.001
NX	0.69 (0.43–1.10)	0.2
M Stage
M0	Ref
M1	4.67 (2.98–7.29)	<0.001
MX	0.56 (0.076–4.08)	0.6
AJCC Stage
Stage I	Ref
Stage II	0.90 (0.34–2.41)	0.8	0.85 (0.31–2.27)	0.7
Stage III	2.0 (1.10–3.65)	0.02	1.22 (0.65–2.28)	0.5
Stage IV	6.28 (3.64–10.84)	<0.001	4.32 (2.43–7.70)	<0.001
Grade
G1 and G2	Ref
G3 and G4	2.94 (1.79–4.84)	<0.001	2.24 (1.33–3.77)	0.002
Risk score
Low	Ref
High	2.73 (1.71–4.35)	<0.001	2.49 (1.52–4.05)	<0.001