Table 2.

Top 10 GWAS Loci associated with α-SMA expression and total collagen content.

SNP	Gene	Locus	Position	A1	A2	MAF	Beta	SE	P
	α-SMA expression
rs8015303	BAZ1A	14q13.2	34316223	G	A	0.06967	−0.7229	0.1313	3.70e-7
rs1012580	NOL10	2p25.1	10725199	A	G	0.2869	−0.4247	0.07935	6.96e-7
rs12722561	IL2RA	10p15.1	6109899	A	G	0.1557	−0.5144	0.09968	1.54e-6
rs12479413	AK311291	2q14.3	129343258	G	A	0.05328	−0.9579	0.1869	1.78e-6
rs1274351	BC037970	10q23.31	92237989	A	G	0.123	−0.5068	0.09921	1.90e-6
rs1274323	HTR7	10q23.31	92264462	G	A	0.127	−0.5038	0.09925	2.17e-6
rs724999	ST6GALNAC3	1p31.1	76961614	A	G	0.07438	−0.8518	0.1741	4.58e-6
rs12207	TUBB3	16q24.3	88529861	A	G	0.05785	−0.9667	0.2023	7.23e-6
rs1345546	NUAK1	12q23.3	104826063	A	G	0.09426	−0.6404	0.1381	1.23e-5
rs10281171	AOAH	7p14.2	36773906	G	A	0.3852	−0.3295	0.07149	1.37e-5
	Total collagen content
rs6908031	FAM46A	6q14.1	81900082	G	A	0.2992	−0.2554	0.04814	8.46e-7
rs2108935	LDB2	4p15.32	16453008	G	A	0.2541	−0.2545	0.05043	2.44e-6
rs7089692	ZWINT	10q21.1	58603555	G	A	0.2459	−0.2431	0.0493	3.89e-6
rs3950119	BCAR3	1p22.1	93821825	G	A	0.2336	0.2674	0.05438	4.10e-6
rs9512950	TPTE2	13q12.11	18870233	C	A	0.2992	−0.2572	0.05406	7.74e-6
rs181662	EMX2	10q26.11	119372445	G	A	0.3279	0.2253	0.04743	7.97e-6
rs13092046	CNTN3	3p12.3	74617642	A	G	0.4262	0.2266	0.04828	9.97e-6
rs2237172	ATXN1	6p22.3	16709566	G	A	0.3512	−0.2444	0.05214	1.03e-5
rs6894788	EFNA5	5q21.3	106875173	G	A	0.2645	0.2476	0.05317	1.16e-5
rs9368758	COL11A2	6p21.32	33245999	A	G	0.06557	−0.4443	0.09714	1.58e-5

The single nucleotide polymorphism is mapped to its nearest gene; A1 is the minor allele, and A2 is the major allele; All positions refer to hg18. α-SMA=alpha-smooth muscle actin, MAF=minor allele frequencies, SE=standard error.