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. Author manuscript; available in PMC: 2020 Sep 18.
Published in final edited form as: ACS Biomater Sci Eng. 2019 May 22;5(8):3766–3787. doi: 10.1021/acsbiomaterials.8b01428

Figure 1.

Figure 1

Top: Representation of the emergence of leader and follower cells within a cell cluster. Bottom: Three key elements of collective cell migration represented with their main components: (a) polarization of cells that leads to the orientation of the cytoskeleton; (b) coordination of actin dynamics between neighboring cells through actin cables; (c) flexibility or dynamic rearrangement of cell–cell contacts due to the retrograde flow of adherens junctions. Adapted with permission from ref 29. Copyright 2016 Springer Nature.