Table 6.
Release kinetic and mechanism of Paracetamol release.
p(AG-m-PmO)1 | 2.0 | 5.5 | 7.4 | 8.0 | p(AG-g-PmO)1 | 2.0 | 5.4 | 7.4 | 8.0 | ||
---|---|---|---|---|---|---|---|---|---|---|---|
ZoM | Co | 1.692 | 1.470 | 1.512 | 1.856 | ZoM | Co | 1.651 | 1.651 | 2.113 | 2.552 |
ko | −0.003 | −0.002 | −0.006 | −0.006 | ko | −0.008 | −0.007 | −0.007 | −0.013 | ||
R2 | 0.887 | 0.822 | 0.713 | 0.751 | R2 | 0.822 | 0.846 | 0.658 | 0.800 | ||
FoM | Co | 5.208 | 3.662 | 1.640 | 1.571 | FoM | Co | 0.686 | 0.316 | 2.004 | 2.203 |
k1 | −0.009 | −0.009 | −0.018 | −0.002 | k1 | −0.002 | −0.002 | −0.008 | −0.007 | ||
R2 | 1.650 | 1.298 | 0.784 | 0.568 | R2 | 0.704 | 0.810 | 0.718 | 0.913 | ||
HM | kh | 0.034 | 0.028 | 0.008 | 0.028 | HM | kh | 0.225 | 0.911 | 0.036 | 0.037 |
R2 | 0.997 | 0.959 | 0.955 | 0.959 | R2 | 0.990 | 0.031 | 0.991 | 0.993 | ||
KPM | n | 0.238 | 0.261 | 0.392 | 0.271 | KPM | n | 0.391 | 0.472 | 0.313 | 0.422 |
kkp | 0.158 | 0.157 | 0.091 | 0.146 | kkp | 0.083 | 0.044 | 0.105 | 0.056 | ||
R2 | 0.983 | 0.891 | 0.841 | 0.935 | R2 | 0.844 | 0.889 | 0.872 | 0.934 | ||
p(AG-m-PmO)2 | 2.0 | 5.5 | 7.4 | 8.0 | p(AG-g-PmO)2 | 2.0 | 5.5 | 7.4 | 8.0 | ||
---|---|---|---|---|---|---|---|---|---|---|---|
ZoM | Co | 1.452 | 1.893 | 1.494 | 1.448 | ZoM | Co | 4.419 | 1.229 | 2.143 | 2.374 |
ko | −0.004 | −0.002 | −0.003 | −0.005 | ko | −0.005 | −0.004 | −0.004 | −0.009 | ||
R2 | 0.752 | 0.705 | 0.728 | 0.726 | R2 | 0.793 | 0.895 | 0.831 | 2.552 | ||
FoM | Co | 5.576 | 10.318 | 1.975 | 2.299 | FoM | Co | 1.488 | 0.347 | 2.143 | 2.851 |
k1 | −0.007 | −0.007 | −0.001 | −0.001 | k1 | −0.001 | −0.002 | −0.004 | −0.007 | ||
R2 | 0.935 | 0.946 | 0.885 | 0.618 | R2 | 0.704 | 0.803 | 0.831 | 0.962 | ||
HM | kh | 0.039 | 0.012 | 0.024 | 0.028 | HM | kh | 0.017 | 0.905 | 0.038 | 0.038 |
R2 | 0.996 | 0.986 | 0.952 | 0.959 | R2 | 0.997 | 0.025 | 0.992 | 0.992 | ||
KPM | n | 0.143 | 0.207 | 0.378 | 0.431 | KPM | n | 0.170 | 0.473 | 0.238 | 0.333 |
kkp | 0.349 | 0.139 | 0.071 | 0.057 | kkp | 0.301 | 0.047 | 0.160 | 0.092 | ||
R2 | 0.925 | 0.897 | 0.929 | 0.968 | R2 | 0.964 | 0.955 | 0.969 | 0.964 | ||
p(AG-m-PmO)3 | 2.0 | 5.5 | 7.4 | 8.0 | p(AG-g-PmO)3 | 2.0 | 5.5 | 7.4 | 8.0 | ||
---|---|---|---|---|---|---|---|---|---|---|---|
ZoM | Co | 0.421 | 1.004 | 0.842 | 0.932 | ZoM | Co | 1.498 | 0.291 | 0.496 | 0.754 |
ko | −0.005 | −0.003 | −0.006 | −0.004 | ko | −0.006 | −0.007 | −0.006 | −0.013 | ||
R2 | 0.928 | 0.759 | 0.839 | 0.639 | R2 | 0.699 | 0.983 | 0.953 | 0.951 | ||
FoM | Co | 1.626 | 1.020 | 3.453 | 1.141 | FoM | Co | 1.384 | 0.717 | 3.437 | 2.897 |
k1 | −0.003 | −0.002 | −0.009 | −0.011 | k1 | −0.001 | −0.002 | −0.003 | −0.005 | ||
R2 | 0.676 | 0.888 | 0.945 | 0.984 | R2 | 0.792 | 0.850 | 0.884 | 0.963 | ||
HM | kh | 0.025 | 0.017 | 0.025 | 0.025 | HM | kh | −0.036 | 0.977 | 0.036 | 0.036 |
R2 | 0.944 | 0.969 | 0.953 | 0.953 | R2 | 0.915 | 0.163 | 0.994 | 0.994 | ||
KPM | n | 0.524 | 0.289 | 0.371 | 0.371 | KPM | n | 0.203 | 0.492 | 0.199 | 0.316 |
kkp | 0.022 | 1.000 | 0.057 | 0.109 | kkp | 0.270 | 0.041 | 0.224 | 0.106 | ||
R2 | 0.933 | 0.957 | 0.954 | 0.852 | R2 | 0.948 | 0.952 | 0.905 | 0.951 |
Fickian diffusion mechanism n ≤ 0.45, non-Fickian (anomalous) diffusion mechanism.0.45 < n < 0.89.