Table 1.
Pharmacokinetic parameters of ferulic acid in serum after taking Si-Wu-Tang.
| Formulation | Dosage | Tmax (min) | Cmax (ng/mL) | AUC0-180 min(min × ng/mL) | Cl (mL/min) | T1/2 (min) |
|---|---|---|---|---|---|---|
| A | 135 mL | 25.7 ± 8.5a | 30.9 ± 8.1a | 3619.7 ± 965.6a | 2310.4 ± 531.1a | 131.7 ± 74.5a |
| 18 g | 32.9 ± 12.7a | 42.1 ± 14.2b | 4404.7 ± 1030.5b | 1892.7 ± 474.8b | 88.2 ± 46.7a | |
| B | 170 mL | 31.1 ± 12.7a | 46.6 ± 25.1b | 4276.2 ± 1140.0b | 2463.4 ± 642.5a | 156.9 ± 79.7a |
| 18 g | 30.0 ± 0a | 44.0 ± 11.6a | 4046.1 ± 752.5b | 2019.5 ± 409.7a | 78.4 ± 12.7b |
Tmax, time at which Cmax was observed; Cmax, maximal measured plasma concentration; AUC, area under the concentration-time curve; Cl, clearance; T1/2, half-life.