Table 1.

Therapeutic depletion of human Treg ^a

Therapies Used	References
Blocking of IL-2R	[133, 134]
Anti-CD25 Ab (daclizumab)
Anti-CD25Ab + radiation
Denileukin diftitox (ONTAK): Killing CD25 + Treg	[135]
Agonistic Abs
Anti-OX40	[136]
Anti-GITR	[137]
Immune checkpoint blockade	[59, 130]
Anti-CCR4 Abs targeting eTreg	[138]
Low-dose metronomic cyclophosphamide
Alone	[139]
With other immune therapies	[140]
Metabolic regulation of Treg	[141]
Targeting “fragility” of Treg	[142]
Interrupting Treg stabilizing pathways	[143]

^aSelected therapies are presented