Table 3.
Anti-virus activity of baicalin
| Virus | Mechanism of action | Dose/concentration | References |
|---|---|---|---|
| A/FM1/1/47 (H1N1) | Interferes with neuraminidase activity | 1.2 μg/mL | Xu et al. [52] |
| Strain A/Thailand/K (H3N2) | Inhibits virus budding and neuraminidases | IC50:49.6 ± 1.07 μg/mL | Gao et al. [3] |
| an-1/04 (H5N1) | Interferes with H5N1 replication | IC50:18.79 ± 1.17 μM | Sithisarn et al. [15] |
| SARS-CoV | 3CLpro | 0.39 μM | Liu et al. (2020) |
| Zika virus | Inhibits virus replication | 0.004 µM | Oo et al. [28] |
| Dengue virus | Inhibits virus replication | IC50:13.5 ± 0.08 μg/mL | Moghaddam et al. [53] |
| Sendai virus | Interferes with neuraminidase | 0.70 μg/mL | Dou et al. [27] |
| Japanese encephalitis virus | Interactions with the E protein of DENV2 | 14.28 µg/mL | Johari et al. [45] |
| CVB3 | Inhibits virus replication | IC50:429.00 ± 22.06 μg/mL | Gao et al. [54] |
| Japanese encephalitis virus | Direct virucidal activity | 14.28 µg/mL | Johari et al. [45] |
| Human HIV-1 | Inhibits HIV-1 induced syncytium formation, HIV-1 p24 antigen, and HIV-1 RT production; inhibits Env-protein mediated fusion of HIV | 4.3 μM | Fesen et al. [55] |
| DENV-2 | Inhibits virus replication | 1.55 μg/mL | Zandi et al. [45] |