Table 4.

Anti-virus activity of apigenin

Virus	Mechanism of action	Dose/concentration	References
EBV	Inhibits expression of EBV lytic proteins, Zta, Rta, EAD, and DNase	200 to 295 μM (24 h); 69 to 158 μM (48 h)	An et al. [56]
African swine fever virus	Inhibits ASFV-specific protein synthesis and viral factory formation	IC50:212.1 ± 11.5 μM	Hakobyan et al. [57]
HCV	Inhibits HCV replication by decreasing mature miR122 expression	5 μM	Shibata et al. [58]
SARS-CoV 3CLpro	Inhibits SARS-CoV 3CLpro	280.8 μM	Ryu et al. [59]
PEDV	Interferes PEDV replication		Choi et al. [60]
FMD virus	Inhibits cytopathogenic effect and FMDV replication		Qian et al. [61]
HIV	Inhibits CYP3A4, slowdown elimination of PIs		Kehinde et al. [62]
Influenza virus		1.43 μg/mL	Liu et al. [51]
Vaccinia virus	Inhibits VV replication		Chang et al. [63]
PV-2		12.2–13.3 μM	Visintini Jaime et al. [64]