TABLE 4.
Demographics from Patients Donating Colon Biopsies.
| Patients | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|
| Diagnosis | CD | CD | UC | UC | Control | Control |
| Age (years) | 9 | 11 | 13 | 15 | 17 | 15 |
| Years since diagnosis | 0.25 | 4.9 | 3.5 | 0 | — | — |
| Disease location/Phenotype | Ileocolitis | Colonic; Upper disease proximal to Ligament of Treitz | Left sided colitis | Pancolitis | — | — |
| Biopsies analyzed in this study | TI, A, D, R | TI, A | A, Da | A, D, R | TI, A, D, R | TI, A, D, R |
| PCDAI | 37.5 | 17.5 | — | — | — | — |
| PUCAI | — | — | 60 | 75 | — | — |
Four random mucosal biopsies were obtained per patient from terminal ileum, ascending colon, descending colon and rectum. For this analysis, only tissue biopsies from endoscopically ulcerated areas of the bowel were analyzed from IBD patients, as indicated below. For controls, all biopsies were analyzed. Inflammation from inflamed areas was confirmed histologically on clinical biopsies.
aPatient 3: On colonoscopy, macroscopic evidence of left colitis involving the descending colon, sigmoid and rectum; Histologic inflammation of ascending and descending colon
Abbreviations: TI, terminal ileum; A, ascending colon; D, descending colon; R, rectum