TABLE 2.
Exploratory CD Biomarkers
| Biomarker | Function | Class |
|---|---|---|
| IL-6 IL-22, IL-2345,46,80,81 | Cytokine | Inflammation |
| NGAL52 | Inflammatory mediator | Inflammation |
| miR-21, miR-31, miR-146a, and miR-37556,60 | microRNA | Inflammation |
| TREM-182 | Triggering receptor on myeloid cells | Inflammation |
| pASCA65 | Autoimmune antibodies targeting neutrophils | Inflammation |
| Oncostatin M57 | Cytokine | Inflammation |
| lower Firmicutes; higher Faecalibacterium60, 62 | Distinct signature in CD phenotypes | Microbiome |
| OmpC, ANCA, I2, A4-Fla2, Fla-X, Cbir165,83,84 | Antibodies to microbial antigens | Microbiome |
| Pro-C4, C4M, C3M, ECM1, BGM, EL-NE, C5M, Pro-C569 | Extracellular matrix proteins | Tissue Injury |
| MMP-3, MMP-9, MMP-1463,70 | Matrix metalloproteases | Tissue Injury |