TABLE 3.
Commercially Available CD Biomarker Panels
| Panel Name | Biomarkers | Matrix | Purpose | Company | References |
|---|---|---|---|---|---|
| PROMETHEUS IBD sgi Diagnostic | ASCA, OMPC, CBir2, A4-Fla2, FlaX, pANCA, ATG16L1, ECM1, NKX2, STAT3, ICAM1, VCAM1, VEGF, CRP, SAA | Blood | IBD vs non-IBD and UC vs CD | Prometheus Laboratories Inc. | https://www.prometheusbiosciences.com/ibd-sgi/ |
| PROMETHEUS Monitr Crohn’s Disease Test | Ang 1, 2; CEACAM 1, hsCRP; EMMPRIN; IL-7; MMP1, 2, 3, 9; SAA 1; TGF-α; VCAM 1 | Serum | Monitor muscosal healing | Prometheus Laboratories Inc. | https://www.prometheusbiosciences.com/monitor/ |
| PROMETHEUS Crohn’s Prognostic | ASCA; OMPC; CBir1; pANCA; NOD2 SNP 8, 12 and 13 | Blood | Probability of disease progression | Prometheus Laboratories Inc. | https://www.prometheusbiosciences.com/crohns-prognostic/ |
| Fingerprint Technology Assays | P1NP, Pro-C3, Pro-C5, Pro-C6; C1M, C3M, C5M and C6M | Serum | Complications for CD | Nordic Bioscience A/S | https://www.nordicbioscience.com/biomarkers-research/nordic-bioscience-assays/ |
| PredictSURE IBD | 15 genes (+2 reference genes) related to CD8+T cells | Blood | Diagnosis; aggressive or milder disease | PredictImmune Ltd | https://www.predictimmune.com/predictsure-ibd-2/ |