Table 2.
Diagnostic performance (all figures are expressed as percentages) of colon capsule endoscopy and CT colonography, according to the intention-to-screen analysis
| CCE | 95% CI | CTC | 95% CI | Diff. | 95% CI | |
|---|---|---|---|---|---|---|
| Any neoplastic lesion1 (regardless of size), no. (%) | 112 (77.2)2 | 94 (66.7)2 | ||||
| Sensitivity | 98.1 | [94.1; 99.4] | 64.8 | [56.7; 72.2] | 33.2 | [22.8; 43.0] |
| Specificity | 76.6 | [68.8; 82.9] | 95.7 | [91.0; 98.0] | − 19.1 | [− 35.6; − 2.4] |
| PPV | 93.6 | [88.2; 96.7] | 96.8 | [92.4; 98.7] | − 3.1 | [− 9.5; 3.9] |
| NPV | 92.0 | [86.2; 95.4] | 57.6 | [49.4; 65.5] | 34.3 | [16.9; 48.7] |
| Accuracy | 93.3 | [87.9; 96.4] | 75.1 | [67.4; 81.5] | 18.2 | [9.7; 26.4] |
| Any neoplastic lesion1 ≥ 6 mm, no. (%)3 | 77 (53.1)2 | 58 (41.1)2 | ||||
| Sensitivity | 96.1 | [91.1; 100] | 79.3 | [68.6; 88.8] | 16.7 | [5.2; 28.2] |
| Specificity | 88.2 | [79.6; 95.3] | 96.3 | [91.1; 100] | − 8.1 | [− 17.1; 0.1] |
| PPV | 90.2 | [83.5; 96.1] | 93.8 | [85.7; 100] | − 3.6 | [− 12.9; 6.5] |
| NPV | 95.2 | [89.2; 100] | 86.9 | [80.0; 93.2] | 8.2 | [0.9; 16.9] |
| Accuracy | 92.4 | [87.5; 96.5] | 89.3 | [83.6; 93.6] | 3 | [− 3.7; 9.8] |
| Any neoplastic lesion1 ≥ 10 mm, no. (%)3 | 37 (25.5)2 | 40 (28.4)2 | ||||
| Sensitivity | 97.3 | [91.1; 100] | 90.0 | [83.9; 93.9] | 7.3 | [− 4.5; 18.6] |
| Specificity | 95.3 | [90.7; 99.0] | 99.0 | [95.6; 100] | − 3.6 | [− 8.3; 1.2] |
| PPV | 87.8 | [76.7; 97.3] | 97.3 | [93.1; 100] | − 9.5 | [− 21.2; 2.9] |
| NPV | 99.0 | [96.8; 100] | 96.1 | [91.5; 98.2] | 2.8 | [− 1.6; 7.4] |
| Accuracy | 95.5 | [92.4; 99.3] | 96.4 | [91.9; 98.4] | − 0.8 | [− 5.2; 4.0] |
CCE colon capsule endoscopy, CTC CT colonography, 95% CI 95% confidence interval, PPV positive predictive value, NPV negative predictive value, Diff. difference
1Any neoplastic lesion includes cancer, advanced and non-advanced adenomas, and advanced and non-advanced serrated lesions
2Prevalence of patients with such lesions at colonoscopy
3Lesion size was estimated at colonoscopy