Table 1.
Clinical characteristics and changes in fasting biochemistry before and after randomization to 7 days of treatment with either prednisolone (10 mg once daily) or prednisolone (10 mg once daily) and a 5α-RI (finasteride [5 mg once daily] or dutasteride [0.5 mg once daily])
| Prednisolone | Prednisolone + 5α-RI | |||
|---|---|---|---|---|
| Clinical Variable | Before | After | Before | After |
| Age, y | 46.7 ± 3.9 | 44.5 ± 2.5 | ||
| Weight, kg | 89.4 ± 2.8 | 86.2 ± 3.9 | ||
| BMI, kg/m2 | 27.8 ± 1.2 | 26.7 ± 0.9 | ||
| SBP, mm Hg | 140.8 ± 3.1 | 141.8 ± 3.0 | ||
| DBP, mm Hg | 86.7 ± 2.5 | 82.0 ± 2.6 | ||
| HbA1c, mmol/mol (20-42) | 34.3 ± 1.2 | 32.1 ± 1.0 | ||
| Fasting glucose, mmol/L | 4.8 ± 0.2 | 5.1 ± 0.3 | 4.5 ± 0.1 | 4.7 ± 0.1 |
| Fasting insulin, pmol/L | 20.4 ± 6.2 | 33.2 ± 9.9 | 33.4 ± 6.9 | 29.4 ± 4.2 |
| HDL cholesterol, mmol/L | 1.4 ± 0.1a | 1.5 ± 0.1a | 1.2 ± 0.1 | 1.3 ± 0.1 |
| Total cholesterol, mmol/L | 5.1 ± 0.5 | 5.0 ± 0.4 | 4.8 ± 0.3 | 4.9 ± 0.4 |
| AST, IU/L (15-42) | 21.7 ± 1.9 | 18.2 ± 1.7 | 19.0 ± 1.3 | 19.5 ± 2.6 |
| Bilirubin, mmol/L (<21) | 19.2 ± 4.0 | 14.0 ± 2.5 | 12.9 ± 1.8 | 11.2 ± 1.4 |
| ALT, IU/L (10-45) | 22.7 ± 3.4 | 24.8 ± 4.1 | 22.1 ± 3.4 | 20.9 ± 3.5 |
| ALP, IU/L (30–130) | 58.7 ± 6.3 | 47.0 ± 11.2 | 62.0 ± 6.6a | 55.8 ± 5.3a |
| Albumin, g/L (32-50) | 37.5 ± 1.1 | 37.5 ± 0.7 | 37.6 ± 0.6 | 36.2 ± 0.6 |
| Palmitic acid 16:00, % | 32.0 ± 3.3c | 28.0 ± 1.2 | 27.5 ± 1.3c | 26.5 ± 1.0 |
| Stearic acid 18:00, % | 22.9 ± 1.9a | 19.2 ± 1.9a | 21.6 ± 1.4a | 18.5 ± 0.9a |
| Oleic acid 18: 1n-9, % | 21.6 ± 4.1a | 28.3 ± 1.7a | 26.9 ± 2.5b | 31.6 ± 2.0b |
| Linoleic acid 18: 2n-6, % | 13.1 ± 1.2 | 16.0 ± 2.9 | 15.0 ± 1.8 | 13.6 ± 1.2 |
| Fasting triglycerides, μmol/L | 659 ± 140 | 568 ± 138 | 823 ± 116 | 786 ± 91 |
| Serum prednisolone, nmol/L | 482 ± 96* | 761 ± 57* | ||
| Serum prednisone, nmol/L | 95 ± 16 | 105 ± 9 | ||
Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; DBP, diastolic blood pressure; DHT, dihydrotestosterone; HDL, high-density lipoprotein; SBP, systolic blood pressure. Local reference ranges are included in parentheses.
a P < 0.05, before vs after treatment.
b P < 0.01, before vs after treatment.
c P < 0.05, before treatment between the 2 groups.
*P < 0.05, after vs after treatment.