Table 2. Adjusted Hazard ratio of developing dementia when taking a PPI compared to a control population using a retrospective cohort.

	Hazard ratio	95% CI
PPI	0.67	0.65 to 0.69*
Adjusted for:
Age	1.06	1.05 to 1.06*
Smoker	0.89	0.85 to 0.92*
BMI	0.95	0.95 to 0.95*
Diabetes	1.18	1.14 to 1.22*
Cardiovascular disease	0.93	0.90 to 0.97*
Depression	1.19	1.16 to 1.23*
Head injury	1.50	1.43 to 1.56*
Vitamin-B12 Deficiency	1.37	1.21 to 1.56*
Anxiolytics	1.62	1.57 to 1.67*
Antidepressants	1.66	1.61 to 1.72*
Anticoagulants	0.87	0.84 to 0.89*
Antiplatelets	1.72	1.66 to 1.79*
Statins	0.86	0.85 to 0.94*
Hormone replacement therapy	0.89	0.85 to 0.94*
Vitamin-B12 Medication	1.41	1.34 to 1.48*
Anaemia Medication	1.10	1.06 to 1.13*
Antihypertensives	0.71	0.69 to 0.74*
Histamine Receptor-2 Medication	0.89	0.85 to 0.94*

*P < 0.05.

Gender, Anaemia and alcohol use were included in the model, but removed as did not reach statistical significance.