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. Author manuscript; available in PMC: 2020 Sep 18.
Published in final edited form as: Mol Psychiatry. 2018 Sep 13;25(4):750–760. doi: 10.1038/s41380-018-0234-y

Figure 4. The protein - protein interaction derived mGluR5 subnetwork is enriched for SCZ risk variants.

Figure 4.

A subnetwork of mGluR5 was constructed that consists of 32 genes based on protein–protein interactions previously reported. Nodes represent genes in the subnetwork and connecting lines (or edges) show previously reported direct protein interactions. Of the 32 genes in the subnetwork, 15 showed gene-wise significance greater than 0.05 in the schizophrenia cohort whereas only 3 showed gene-wise significance in the Crohn’s disease cohort (Figure 4). Gray = all associated genes, gray rectangle = schizophrenia only, gray triangle = Crohn’s only, gray diamond = both.