Table 8.
Pertinent AEs by Treatment
| Pertinent AEs | TARE_alone | TARE_sorafenib | TARE_alternative | |||
|---|---|---|---|---|---|---|
| Grade 1–2 | Grade 3–4 | Grade 1–2 | Grade 3–4 | Grade 1–2 | Grade 3–4 | |
| Constitutional symptoms | ||||||
| Fever | 4 (6.1) | 0 | 2 (2.5) | 0 | 1 (3.2) | 0 |
| Fatigue | 33 (50.0) | 0 | 44 (55.7) | 0 | 13 (41.9) | 0 |
| Weight loss | 2 (3.0) | 0 | 3 (3.8) | 0 | 1 (3.2) | 0 |
| Loss of appetite | 3 (4.5) | 0 | 9 (11.4) | 0 | 2 (6.5) | 0 |
| Dermatological | 1 (1.5) | 0 | 19 (24.1) | 2 (2.5) | 1 (3.2) | 0 |
| Gastrointestinal disorders | ||||||
| Diarrhea | 0 | 0 | 15 (19.0) | 0 | 0 | 0 |
| Nausea or vomiting | 14 (21.2) | 0 | 34 (43.0) | 0 | 9 (29.1) | 0 |
| Abdominal discomfort | 10 (15.1) | 3 (4.5) | 29 (36.7) | 1 (1.3) | 11 (35.5) | 0 |
| Anorexia | 3 (4.5) | 0 | 6 (7.6) | 0 | 1 (3.2) | 0 |
| Constipation | 2 (3.0) | 0 | 5 (6.3) | 0 | 0 | 0 |
| Gastroesophageal varices hemorrhage | 0 | 0 | 0 | 2 (2.5) | 0 | 1 (3.2) |
| Gastritis | 0 | 0 | 1 (1.3) | 0 | 0 | 1 (3.2) |
| Pancreatitis | 0 | 1 (1.5) | 0 | 0 | 0 | 0 |
| Cholecystitis | 0 | 0 | 0 | 0 | 0 | 1 (3.2) |
| Intra-abdominal bleeding | 0 | 1 (1.5) | 0 | 1 (1.3) | 0 | 0 |
| Liver disorders | ||||||
| Ascites | 4 (6.1) | 4 (6.1) | 6 (7.6) | 2 (2.5) | 4 (12.9) | 2 (6.5) |
| REILD | 0 | 0 | 0 | 0 | 0 | 0 |
| Hepatic encephalopathy | 0 | 3 (4.5) | 0 | 2 (2.5) | 0 | 0 |
| Respiratory symptoms | ||||||
| Dyspnea | 4 (6.1) | 1 (1.5) | 4 (5.1) | 0 | 3 (9.7) | 0 |
| Cough | 1 (1.5) | 0 | 0 | 0 | 0 | 0 |
| Pleural effusion | 0 | 0 | 0 | 1 (1.3) | ||
| Radiation-induced pneumonitis | 0 | 0 | 0 | 0 | 0 | 0 |
| Laboratory abnormalities | ||||||
| Hyperbilirubinemia | 13 (19.7) | 3 (4.5) | 24 (30.4) | 1 (1.3) | 7 (22.6) | 0 |
| Hypoalbuminemia | 10 (15.1) | 0 | 19 (24.1) | 0 | 6 (19.3) | 0 |
| Anemia | 5 (7.5) | 0 | 11 (13.9) | 0 | 6 (19.3) | 1 (3.2) |
| Thrombocytopenia | 12 (18.2) | 0 | 17 (21.5) | 3 (3.8) | 10 (32.3) | 0 |
| Leukopenia | 11 (16.7) | 2 (3.0) | 13 (16.4) | 3 (3.8) | 5 (16.1) | 0 |
| Renal dysfunction | 0 | 0 | 2 (2.5) | 0 | 0 | 0 |
| Increased AST | 4 (6.0) | 0 | 8 (10.1) | 0 | 4 (12.9) | 0 |
| Increased ALT | 2 (3.0) | 0 | 2 (2.5) | 1 (1.3) | 3 (9.7) | 0 |
| Increased ALP | 1 (1.5) | 0 | 7 (8.9) | 0 | 2 (6.5) | 0 |
| Other | ||||||
| Electrolyte imbalance | 0 | 1 (1.5) | 2 (2.5) | 0 | 0 | 0 |
| Sepsis | 0 | 1 (1.5) | 0 | 2 (2.5) | 0 | 0 |
Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase.