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. Author manuscript; available in PMC: 2020 Sep 18.
Published in final edited form as: Am J Surg Pathol. 2018 Mar;42(3):293–305. doi: 10.1097/PAS.0000000000000985

TABLE 1.

Clinical Characteristics of Patients With BI-ALCL and LNI (n = 14)

Case No. References Age (y) Reason For Implants Clinical Presentation Extent of Periimplant Capsule Involvement Timing of LNI*
1 Aladily11 63 Cancer Effusion Within (+) 37
2 Alobeid et al16 68 Cancer L axillary node Within (−) 5
3 Aladily11 57 Cosmetic Effusion, mass Beyond Synchronous
4 Clemens et al5 52 Cosmetic Mass Beyond Synchronous
5 Miranda et al3 40 Cosmetic L axillary node Beyond (−) 36
6 George17 67 Cancer Effusion Within (+) 6
7 Estes et al18 77 Cosmetic Effusion, mass Within (+) 13
8 Miranda et al3 41 Cosmetic Effusion, mass Beyond (+) 21
9 Unpublished 72 Cancer Effusion, mass Beyond (+) 36
10 Clemens et al5 54 Cancer Effusion, mass Within (+) 22
11 Acevedo-Banez et al19 50 Cancer Mass Beyond Synchronous
12 Tardio and Granados20 51 Cancer L axillary node, mass Within Synchronous
13 Laurent et al21 83 Cancer Mass Beyond Synchronous
14 Unpublished 51 Cosmetic R axillary node, mass Beyond Synchronous
Location of LNI Clinical Stage Ann Arbor on Presentation Clinical Stage MDACC† on Presentation Management Time Follow-up (mo) Outcome Cause of Death
Axilla I IB Surgery, chemotherapy 100 CR NA
Axilla bilateral II IIB Surgery, chemotherapy 71 CR NA
Supraclavicular, internal mammary II III Surgery, chemotherapy, radiotherapy 100 CR NA
Axilla, infraclavicular II III Surgery, chemotherapy, radiotherapy 7 DOD Mediastinal mass with bronchial compression
Axilla, supraclavicular, internal mammary, mediastinal, infraclavicular II III Surgery, chemotherapy, radiotherapy, ASCT 100 CR NA
Axilla, mediastinal, internal mammary I IB Surgery, chemotherapy 14 CR NA
Axilla I IB Surgery, chemotherapy, radiotherapy 41 CR NA
Axilla I IIA Surgery, chemotherapy, radiotherapy 47 CR NA
Axilla I IIA Surgery 38 AWD NA
Axilla I IIB Surgery, chemotherapy 30 CR NA
Axilla contralateral IV IV Surgery, chemotherapy, radiotherapy 20 CR NA
Axilla II IIB Surgery, chemotherapy, radiotherapy 29 CR NA
Axilla II III Surgery, chemotherapy, immunotherapy 13 DOD ALCL (manner of death not determined)
Axilla II III Surgery, chemotherapy, radiotherapy 60 CR NA

Surgical therapy encompasses partial surgery, complete surgery.

*

Timing of LNI:synchronous: LNI and periimplant capsule BI-ALCL diagnoses at the same time; (+ value): months after periimplant capsule diagnosis; (−value): months before periimplant capsule diagnosis.

†

Clinical staging according to Clemens et al5.

ASCT indicates autologous stem cell transplant; CR, complete remission; NA, not available.