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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Adv Healthc Mater. 2020 Mar 8;9(15):e1901580. doi: 10.1002/adhm.201901580

Figure 1.

Figure 1.

Schematic illustrating the development of NICE and bioconditioned NICE (bNICE) scaffolds. (A) Nanocomposite reinforcement between nSil and crosslinked GelMA and the ionic-covalent entanglement of the independent polymeric networks of ÎșCA and GelMA allows for NICE ink to be both elastic and highly printable. (B) iP-hMSCs were seeded on NICE scaffolds and cultured in the presence of GW9662 for 10 days followed by decellularization. The scaffolds modified with iP-hMSC-derived ECM, or bNICE, were seeded with hMSCs and evaluated in vitro for osteogenic differentiation after 8 and 21 days of culture.