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. 2020 Sep 18;49(6):763–773. doi: 10.1016/j.hrtlng.2020.08.025

Table 1.

Drugs that have been studied in relief of COVID-19 clinical presentation.

Drug Adult Dosage Pediatric Dosage Route of Administration
Chloroquine phosphate 500 mg (300 mg for chloroquine base) twice daily25 Not recommended Oral
Hydroxychloroquine 200 mg twice daily26 Not recommended Oral
Lopinavir/Ritonavir 400mg/100 mg (2 capsules each time) twice daily26 Lopinavir:BW1 (kg):
  • 7–15 kg: 12 mg/3 mg/kg/time, twice daily

for 1–2 weeks
  • 15–40: 10 mg/2.5 mg/kg/time, twice daily

for 1–2 weeks
  • 40: 400 mg/100 mg/time, twice daily

for 1–2 weeks27
Oral
Ribavirin 500 mg twice dailyin combination with IFN-α or lopinavir/ritonavir25 10 mg/kg every time (maximum 500 mg every time), 2–3 times daily 27 IV infusion
IFN-α2 5 million U twice daily25 200,000–400,000 IU/kg or 2–4 μg/kg in 2 mL sterile water, twice
daily for 5–7 days 27
Vapor inhalation (nebulization)
Umifenovir 200 mgthree times daily26 Not recommended Oral
Remdesivir 200 mg loading dose on the first day
Followed by 100 mg once daily 28
  • BW1 of 3.5-40 kg: 5 mg/kg loading dose on the first day followed by 2.5 mg/kg once daily from the second day

  • BW1 of ≥ 40 kg: similar to the adult dosage29.

IV infusion
Tocilizumab 8 mg/kg every 4 weeks 30 Not recommended IV infusion
(during 60 min)
Teicoplanin 400 mg daily31 Not recommended IV infusion
Favipiravir 1600-2400 mg loading dose on the first day
Followed by 200-600 mg twice daily 26
Not recommended Oral
1

Body weight

2

Interferon alpha