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. 2020 Sep 18;15(9):e0238600. doi: 10.1371/journal.pone.0238600

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© 2020 Ilić et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 9 — Effect of 13 cRA on MDA (A), GSH (B) and liver CAT activity (C) of rats fed standard or high fat diets. Rats were fed either STD or HFD for 9 weeks ad libitum. 13 cRA was orally administered to rats via a gastric tube in two different concentrations (7.5 mg/kg, 15 mg/kg) during 30 days. Liver was isolated when animals were sacrificed, on the 60^th day of the experiment. Number of rats per group: 6. *Different in relation to STD-C (* P<0.05; ** P<0.01; *** P<0.001). +Different in relation to HFD-C (+ P<0.05; ++ P<0.01). XDifferent in relation to STD+7.5 (13 cRA) (x P<0.05; xxx P<0.001). ^⁰Different in relation to STD+15 (13 cRA) (^⁰ P<0.05; ^⁰⁰⁰ P<0.001). ~Different in relation to HFD+7.5 (13 cRA) (~ P<0.05; ~~ P<0.01). Data are expressed as mean ± SEM. Data were analysed using Kruskal-Wallis ANOVA (STATISTICA 13 StatSoft, Tulsa, OK, USA).