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. 2020 Sep 19;34(4):209–220. doi: 10.1016/j.tmrv.2020.09.005

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Pleiotropic Platelet membrane receptors by which Platelets can interact with bacteria and numerous immune cells such as B-cells, T-cells, monocytes, neutrophils, epithelium, endothelium and tumor cells. Arrows and brackets show some of the major interactions. CD40, CD40 molecule; CD40L, CD40 ligand (CD154); sCD40L, soluble CD40L; LPS, Lipopolysaccharide; LP, Lipoprotein; dsRNA, Double-stranded RNA; ssRNA, Single-stranded RNA; CAPs, carboxy(alkylpyrrole) protein adducts; PMV, Platelet microvesicule; IL-1β, Interleukin-1 beta; NAP-2, Neutrophil Activating protein-2; EMT, epithelial-mesenchymal transition proteins; CXCL4, Chemokine (C-X-C motif) ligand 4; CXCL7, Chemokine (C-X-C motif) ligand 7; CCL3, Chemokine (C-C motif) ligand 3; CCL5, Chemokine (C-C motif) ligand 5; TGF-β, Transforming growth factor beta; TC-1, Thrombocidin-l ;TC-2, thrombocidin-lI; CLEC-2, C-type lectin domain family 2; DC-SIGN, Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin; TLRs, Toll Like Receptors.