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. Author manuscript; available in PMC: 2021 Oct 10.
Published in final edited form as: J Control Release. 2020 Jul 16;326:222–244. doi: 10.1016/j.jconrel.2020.07.011

Figure 9.

Figure 9.

Respirable controlled release polymeric colloid (RCRPC) of bosentan for the management of pulmonary hypertension. (A) Representative transmission electron microscope micrograph of the optimized bosentan RCRPC. (B) Bosentan concentration in plasma of rats after the oral administration of bosentan suspension and intratracheal delivery of the optimized bosentan RCRPC. (C) Pharmacokinetics parameters of bosentan in plasma following IT delivery of the optimized RCRPC and oral formulation of bosentan suspension given to rats. Means ± SD are shown. *P < 0.05 when compared with oral administration. Redrawn and replotted based on data presented in [201].