Skip to main content
. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: Clin Cancer Res. 2020 Jun 22;26(18):4852–4862. doi: 10.1158/1078-0432.CCR-20-0638

Figure 2. APOBEC mutation signature in somatic BRCA-mutant patients.

Figure 2.

The “Lego” plot on the left is the study data (all somatic mutations in the cohort). The “Lego” plot on the right is a “reference” for comparison: the APOBEC mutation signature. It also has the plot axes labeled. The rows are not mutational signature, but rather the whole plot is a mutation signature. The APOBEC mutation signature was clearly observed in this cohort. Approximately 40% of mutations were assignable to the APOBEC mutation signature (back row of bars in the “Lego” plot, COSMIC signatures 2+13), summing mutations across the 29 patients that were found to carry somatic BRCA mutations. Other contributors to the mutations in these BRCA-mutant patients were the “aging” signature (COSMIC Signature 1) and the “BRCA” signature (COSMIC Signature 3).