TABLE 3.
Univariate and multivariable associations between clinicopathological factors and avoidance of ALND (with retrieval of ≥ 3 SLNs and nodal pCR)
| Univariable | Multivariable | |||
|---|---|---|---|---|
| Odds ratio (95% CI) | P | Odds ratio (95% CI) | P | |
| Age per 5-year increase | 0.93 (0.87, 1.00) | 0.07 | ||
| BMI, per 5-unit increase | 0.95 (0.83, 1.09) | 0.46 | ||
| Palpable node at presentation | 1.23 (0.84, 1.81) | 0.30 | ||
| Palpable tumor at presentation | 0.88 (0.51, 1.52) | 0.66 | ||
| cT at presentation ref: 1 | ||||
| 2 | 1.18 (0.76, 1.84) | 0.46 | ||
| 3 | 1.15 (0.68, 1.95) | 0.59 | ||
| Subtype ref HR+ HER2− | ||||
| HR+ HER2+ | 4.80 (3.03, 7.60) | < 0.001 | 3.93 (2.40, 6.44) | < 0.001 |
| HR− HER2+ | 13.5 (7.32, 24.9) | < 0.001 | 8.24 (4.16, 16.3) | < 0.001 |
| HR− HER2− | 3.06 (1.88, 4.97) | < 0.001 | 1.99 (1.15, 3.46) | 0.01 |
| Histology ref: ductal | ||||
| Lobular and mixed | 1.25 (0.66, 2.39) | 0.50 | 0.75 (0.35, 1.62) | 0.47 |
| Micropapillary and mixed | 0.26 (0.11, 0.59) | 0.001 | 0.46 (0.19, 1.15) | 0.10 |
| Apocrine and mixed | 0.48 (0.23, 1.02) | 0.06 | 0.63 (0.25, 1.60) | 0.33 |
| Other | 0.58 (0.22, 1.55) | 0.28 | 0.55 (0.19, 1.63) | 0.28 |
| LVI | 0.24 (0.17, 0.36) | < 0.001 | 0.28 (0.18, 0.43) | < 0.001 |
| Grade III ref: I/II | 3.69 (2.55, 5.33) | < 0.001 | 2.51 (1.60, 3.94) | < 0.001 |
Modeling odds of having ≥ 3 SLNs and nodal pCR (n = 237) versus all other patients (n = 336).
ALND axillary lymph node dissection, SLN sentinel lymph node, pCR pathologic complete response, CI confidence interval, BMI body mass index, HR hormone receptor, LVI lymphovascular invasion