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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: FASEB J. 2020 May 23;34(7):8810–8823. doi: 10.1096/fj.202000651

Figure 1. Structure of GPNMB.

Figure 1.

This membrane bound protein contains a signaling domain (SP), an RGD motif in the N-terminal domain (NTD), a polycystic kidney disease (PKD) domain, and a Kringle-like domain (KLD) in the extracellular portion. The cytosolic domain, which is separated by the transmembrane domain (TM), consists of a half immunoreceptor tyrosine-based activation motif (hemITAM), and a lysosomal/endosomal targeting dileucine motif (DL) in the C-terminal domain (CTD). Solid stars indicate potential N-glycosylation sites. A GPNMB isoform is identified where 12 amino acids are inserted between amino acid 339 and 340 in GAP1, most likely due to alternative splicing.