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Top: Structure of vancomycin and key analogues with H-bonding interactions between vancomycin and model ligands indicated by dashed lines. Middle: Added peripheral modifications that synergistically improve activity by inducing membrane permeabilization (C1) or directly inhibiting transglycosylase (CBP), both independent of D-Ala-D-Ala/D-Lac binding. Bottom: VanA VRE antimicrobial activity.
