Table 2.

Summary of ncRNAs targeting NLRP3 inflammasome signaling pathway in endothelial dysfunction.

ncRNA	Target gene	Effect on NLRP3 activation	Functions	Disease/research context	References
miR-22	NLRP3	Down	•↓ EC apoptosis •↓ Pro-inflammatory cytokines •↑ Tube formation	Coronary atherosclerosis	135
miR-495	NLRP3	Down	•↓ EC inflammation •↓ EC apoptosis •↑ EC proliferation	Myocardial ischemia/reperfusion injury	136
miR-15a	FOXO1	Down	•↓ EC inflammation	Diabetic retinopathy	137
miR-126	HMGB1	Down	•↓ EC inflammation	Diabetic retinopathy	138
miR-590-3p	NLRP1, NOX4	Down	•↓ EC inflammation, pyroptosis	Diabetic retinopathy	139
miR-20a	TXNIP, TLR4	Down	•↓ EC inflammation •↓ ROS generation	Atherosclerosis	140
miR-30c-5p	FOXO3	Down	•↓ EC inflammation, pyroptosis	Atherosclerosis	141
miR-383-3p	IL1R2	Down	•↓ EC inflammation •↓ EC apoptosis •↑ Tube formation	Coronary atherosclerosis	142
miR-20b	TXNIP	Down	•↓ EC senescence	H2O2-induced EC senescence	143
miR-101-3p	Bim	Down	•↓ EC apoptosis	Serum deprivation-induced EC apoptosis	144
miR-200a-3p	Keap1, NLRP3	Up	•↑ EC inflammation	Sepsis-induced brain injury	145
miR-92a	SIRT1, KLF2, and KLF4	Up	•↑ Endothelial innate immunity •↓ NO bioavailability	Atherosclerosis	146
miR-125a-5p	TET2	Up	•↑ EC inflammation, pyroptosis	Atherosclerosis	147
LncRNA MALAT1	miR-22	Up	•↑ EC inflammation, pyroptosis	Atherosclerosis	148
LncRNA MEG3	miR-223	Up	•↑ EC pyroptosis	Atherosclerosis	149
LncRNA NEXN-AS1	/	Down	•↓ EC pyroptosis	Atherosclerosis	94
Hsa_circ_0068087	miR-197	Up	•↑ EC inflammation •↑ Tube formation	T2DM	150