Table 1.
Effect of Xist knockdown on the expression of LPS-induced acute inflammatory genes in J774A.1 cells
| Gene | Gene title | Expression change in response to LPS | |||
|---|---|---|---|---|---|
| Control | Xist knockdown | ||||
| p value | Fold increase | p value | Fold increase | ||
| Il1a | Interleukin 1 alpha | 0.00039 | 1059.9 | 0.013 | 479.5 |
| Il6 | Interleukin 6 | 0.0029 | 183.3 | 0.0012 | 270.9 |
| Il1b | Interleukin 1 beta (Il1b), mRNA | 0.0014 | 149 | 0.002 | 111.8 |
| Ccl5 | Chemokine (C–C motif) ligand 5 | 0.0016 | 28.1 | 0.0012 | 28 |
| Ptgs2 | Prostaglandin-endoperoxide synthase 2 | 0.0055 | 19.8 | 0.0012 | 16.7 |
| Tnf | Tumor necrosis factor (Tnf), mRNA | 0.003 | 6.6 | 0.0012 | 6.8 |
| Il1rn | Interleukin 1 receptor antagonist | 0.0033 | 6.1 | 0.0021 | 5.7 |
| Nlrp3 | NLR family, pyrin domain containing 3 | 0.005 | 4.8 | 0.0012 | 4.9 |
| Ptges | Prostaglandin E synthase | 0.0033 | 3 | 0.004 | 2.8 |
| Icam1 | Intercellular adhesion molecule 1 | 0.0083 | 2.9 | 0.0021 | 2.9 |
| Nupr1 | Nuclear protein transcription regulator 1, nuclear protein 1 | 0.0049 | 2.6 | 0.0016 | 2.6 |
| Serpinb9 | Serine (or cysteine) peptidase inhibitor, clade B, member 9 | 0.0053 | 2.3 | 0.0038 | 2.9 |
| Fcgr2b | Fc receptor, IgG, low affinity Ilb | 0.014 | 1.7 | 0.0062 | 2 |
| Stat3 | Signal transducer and activator of transcription 3 | 0.013 | 1.7 | 0.0043 | 1.7 |
| Plscr1 | Phospholipid scramblase 1 | 0.027 | 1.5 | 0.027 | 1.6 |