Figure 3.
Affective pain response of female and male rats after inhibition of thalamic GAD67 positive cells. PEAP testing of rats with VZV associated pain was completed after administering a proestrus dose of estradiol with and without treatment with clozapine N-oxide (CNO). A reduced amount of time spent on the dark side indicates a greater pain response. Testing was completed in female (panels A, B and C) or males (panels D, E and F) rats. Testing was completed once a week for three weeks. Asterisk indicates a significant difference (p<0.05) between groups within that testing period, there were 10 animals per group.