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. 2020 Sep 18;10:15336. doi: 10.1038/s41598-020-70885-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Spatial variation in biochemical deficiency in skeletal muscle biopsy cross-section taken from patient with a m.14709T>C MT-TE tRNA variant. (A) One of 9 raw pseudo-images from IMC from P09 [point mutation in mitochondrial-encoded tRNA (MT-TE)]. Dystrophin (a membrane-associated cytoskeletal protein) expression levels shown in grey, NDUFB8 in magenta. (B) Quantification of spatial pattern in NDUFB8 expression levels (theta) observed in (A). Continuous range of theta values represented by colour (orange fibres are deficient). (C) Representation of biochemically deficient fibres (yellow) and their neighbours (blue) after analysis of data from (A) (and VDAC1 data and comparison with controls). Fibre area in both panels represented by circle area.