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. 2020 Sep 18;10:15329. doi: 10.1038/s41598-020-71567-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Migration of the epithelium in wound closure experiment. a Orientation of the wound in comparison to 1 μm topographical features. b Phase contrast images of the wound boundary progression over time. Scale bar 100 μm. c Kymographs of the wound closure (averaged over the entire field) from the phase contrast images. Yellow lines represent the progression of the front and the rear end of the epithelium (defined as 300 μm deep into the wound at the beginning of the process). The wound front in the parallel configuration during the third phase is indicated by a yellow dotted line due to its difficult identification. d Low magnification phase contrast images of the in vitro wound healing during migration on the three samples (flat, orthogonal, and parallel) right after PDMS slice has been peeled off and after 144 h (6 d). Light blue lines define the wound edges.