Table 6.

Analysis of different prognostic factors in relation to DFS in malignant phyllodes

		Malignant DFS rate			Median (m)
Factors	N	1 yr.	2 yrs.	3 yrs.	(95% CI)	p value
All	33	66.3	52.9	42.3	32.5(3.4–61.5)	NA
Age group (yrs.)
< 40 yrs.	11	70.7	58.9	39.3	32.5(1.0–68.1)	0.815
≥ 40 yrs.	22	57.2	50.1	50.1	NA
Laterality*
Left	16	70.9	63.0	63.0	44.6(1.0–103.1)	0.119
Right	16	61.1	40.7	NA	17.2(4.6–29.8)
Family history
Negative	26	69.7	57.5	46.0	32.5(5.1–59.8)	0.320
Positive	7	53.6	NA	NA	12.1(2.3–22.1)
Menopause
Post	15	65.2	55.9	NA	NA	0.869
Pre	18	67.6	51.5	41.2	32.5(5.1–59.9)
Multicentricity
Multiple	2	100	NA	NA	17.2	NV
Single	31	63.7	54.2	43.4	32.5(1.0–64.4)
Pathological size
≤ 5 cm	13	55.1	44.1	44.1	12.2(9.3–15.1)	0.305
> 5 cm	20	73.3	58.7	44.0	32.5(0.5–64.7)
Axillary dissection
No	17	61.4	61.4	61.4	NA	0.784
Yes	16	71.6	47.7	31.8	17.2(1.0–38.3)
Surgical margin
Negative	19	79.4	71.5	71.5	44.6	0.007
Positive	6	41.7	20.8	20.8	6.1(1.0–12.4)
Closed	8	50.0	33.3	NA	3.1(1.0–13.9)
Metastasis
No	25	72.0	65.5	49.1	32.5	0.049
Yes	8	37.5	25.0	25.0	9.1(1–21.7)
Radiotherapy
No	26	60.5	54.5	54.5	NA	0.826
Yes	7	85.7	57.1	42.9	32.5(1.0–71.7)
Chemotherapy
No	27	69.4	57.3	42.9	32.5(1.0–63.9)	0.125
Yes	6	33.3	33.3	33.3	3.1(1.0–11.9)
Type of surgery
Mastectomy	17	84.6	66.6	44.4	32.5(5.0–59.6)	< 0.001
Lumpectomy	2	NA	NA	NA	1
WLE	14	42.1	42.1	42.1	11.1(3.6–18.7)