Figure 3.
Efficacy of ICAM-1 CAR T Cells in a Systemic Xenograft Model
(A) Whole-body bioluminescence images of Hs746t-engrafted NSG mice without treatment (no T), or treated with either NT or ICAM-1 CAR T cells (CP5). (B) Quantitation of total body bioluminescence (n = 4–6 mice per cohort). Thick lines indicate mean bioluminescence intensity, while thin lines represent data for each individual mouse. (C) Summary of body weight changes over time. Data represent mean ± SD (n = 4–6). (D) Kaplan-Meier survival curves (log-rank [Mantel-Cox] test; ∗p < 0.05, ∗∗p < 0.01). (E) Representative PET/CT (coronal view of 20-mm-thick plane, maximum intensity projection) images showing 18F-NOTAOCT uptake in mice left untreated or treated with either NT or ICAM-1 CAR T cells.