Table 2.
Area under the curve (AUC) of nitrosative stress biomarkers and glutathione between patients with morbid obesity (OB) and morbid obesity and hypertension (OB+HYP); patients with morbid obesity (OB) and morbid obesity and metabolic syndrome (OB+MS) as well as patients with morbid obesity and hypertension (OB+HYP) and morbid obesity and metabolic syndrome (OB+MS); reduced glutathione (GSH), oxidized glutathione (GSSG), myeloperoxidase (MPO) nitric oxide (NO).
| OB vs. OB+HYP | ||||||||
|---|---|---|---|---|---|---|---|---|
| AUC | 95% CI | p value | Cutoff | Sensitivity % | 95% CI | Specificity % | 95% CI | |
| MPO | 0.8021 | 0.6770 to 0.9271 | 0.0008 | >0.1358 | 75 | 50.50% to 89.82% | 76.67 | 59.07% to 88.21% |
| NO | 0.6583 | 0.4810 to 0.8357 | 0.0796 | < 10.31 | 75 | 50.50% to 89.82% | 73.33 | 55.55% to 85.82% |
| S-nitrosothiols | 0.6375 | 0.4573 to 0.8177 | 0.128 | <20.24 | 62.5 | 38.64% to 81.52% | 63.33 | 45.51% to 78.13% |
| Peroxynitrite | 0.9292 | 0.8568 to 1.000 | <0.0001 | >5.705 | 87.5 | 63.98% to 97.78% | 90 | 74.38% to 96.54% |
| Nitrotyrosine | 0.6167 | 0.4442 to 0.7891 | 0.1965 | <5.572 | 56.25 | 33.18% to 76.90% | 60 | 42.32% to 75.41% |
| Total glutathione | 0.619 | 0.4355 to 0.8024 | 0.1853 | >46.46 | 62.5 | 38.64% to 81.52% | 67.74 | 50.14% to 81.43% |
| GSSG | 0.7036 | 0.5191 to 0.8882 | 0.0234 | >31.56 | 68.75 | 44.40% to 85.84% | 64.52 | 46.95% to 78.88% |
| GSH | 0.6573 | 0.5000 to 0.8145 | 0.0799 | <12.39 | 62.5 | 38.64% to 81.52% | 64.52 | 46.95% to 78.88% |
| Redox potential | 0.7333 | 0.5848 to 0.8819 | 0.011 | <3.618 | 66.67 | 41.71% to 84.82% | 74.19 | 56.75% to 86.30% |
| OB vs. OB+MS | ||||||||
| AUC | 95% CI | p value | Cutoff | Sensitivity % | 95% CI | Specificity % | 95% CI | |
| MPO | 0.8563 | 0.7481 to 0.9644 | <0.0001 | >0.1705 | 75 | 50.50% to 89.82% | 76.67 | 59.07% to 88.21% |
| NO | 0.7833 | 0.6525 to 0.9141 | 0.0017 | >15.72 | 75 | 50.50% to 89.82% | 73.33 | 55.55% to 85.82% |
| S-nitrosothiols | 0.8458 | 0.7109 to 0.9807 | 0.0001 | >24.02 | 81.25 | 56.99% to 93.41% | 83.33 | 66.44% to 92.66% |
| Peroxynitrite | 0.9125 | 0.8317 to 0.9933 | <0.0001 | >5.481 | 81.25 | 56.99% to 93.41% | 83.33 | 66.44% to 92.66% |
| Nitrotyrosine | 0.8125 | 0.6742 to 0.9508 | 0.0005 | >7.339 | 75 | 50.50% to 89.82% | 76.67 | 59.07% to 88.21% |
| Total glutathione | 0.5484 | 0.3708 to 0.7260 | 0.59 | >40.60 | 43.75 | 23.10% to 66.82% | 45.16 | 29.16% to 62.23% |
| GSSG | 0.5948 | 0.4208 to 0.7687 | 0.2913 | >30.06 | 62.5 | 38.64% to 81.52% | 61.29 | 43.82% to 76.27% |
| GSH | 0.5948 | 0.4232 to 0.7663 | 0.2913 | <12.78 | 62.5 | 38.64% to 81.52% | 61.29 | 43.82% to 76.27% |
| Redox potential | 0.6215 | 0.4418 to 0.8012 | 0.1855 | <6.495 | 60 | 35.75% to 80.18% | 58.06 | 40.77% to 73.58% |
| OB+HYP vs. OB+MS | ||||||||
| AUC | 95% CI | P value | Cutoff | Sensitivity % | 95% CI | Specificity % | 95% CI | |
| MPO | 0.6523 | 0.4540 to 0.8507 | 0.1416 | >0.1743 | 62.5 | 38.64% to 81.52% | 62.5 | 38.64% to 81.52% |
| NO | 0.8594 | 0.7158 to 1.000 | 0.0005 | >14.11 | 81.25 | 56.99% to 93.41% | 81.25 | 56.99% to 93.41% |
| S-nitrosothiols | 0.9141 | 0.8106 to 1.000 | <0.0001 | >22.41 | 81.25 | 56.99% to 93.41% | 81.25 | 56.99% to 93.41% |
| Peroxynitrite | 0.5391 | 0.3292 to 0.7489 | 0.7063 | >7.290 | 56.25 | 33.18% to 76.90% | 56.25 | 33.18% to 76.90% |
| Nitrotyrosine | 0.8945 | 0.7781 to 1.000 | 0.0001 | >6.945 | 81.25 | 56.99% to 93.41% | 81.25 | 56.99% to 93.41% |
| Total glutathione | 0.5703 | 0.3595 to 0.7811 | 0.4975 | <44.41 | 62.5 | 38.64% to 81.52% | 62.5 | 38.64% to 81.52% |
| GSSG | 0.6367 | 0.4351 to 0.8384 | 0.1871 | <32.50 | 62.5 | 38.64% to 81.52% | 62.5 | 38.64% to 81.52% |
| GSH | 0.5586 | 0.3551 to 0.7620 | 0.5718 | >11.52 | 56.25 | 33.18% to 76.90% | 56.25 | 33.18% to 76.90% |
| Redox potential | 0.5778 | 0.3630 to 0.7926 | 0.4679 | >3.081 | 53.33 | 30.12% to 75.19% | 53.33 | 30.12% to 75.19% |