Table 2.
Effects of LPS treatment or CLP on hepatic injury and renal function in 5/6 nephrectomized mice.
| Parameter | 5/6 nephrectomized mice (sham) | 5/6 nephrectomized mice | ||
|---|---|---|---|---|
| PBS treated (n = 6) | LPS (2 mg/kg) treated (n = 6) | PBS treated (n = 6) | LPS (2 mg/kg) treated (n = 6) | |
| Urea (mM/L) | 8.10 ± 0.32 | 15.92 ± 2.11 | 16.98 ± 1.02a | 37.65 ± 1.85a,b |
| Creatinine (μM/L) | 29.86 ± 0.78 | 30.17 ± 2.57 | 44.94 ± 2.55a | 58.12 ± 2.44a,b |
| ALT (U/L) | 26.75 ± 2.74 | 51.55 ± 1.88 | 31.88 ± 2.88 | 82.54 ± 9.44a,b |
|
| ||||
| Sham operated (n = 6) | CLP (n = 6) | Sham operated (n = 6) | CLP (n = 6) | |
| Urea (mM/L) | 8.12 ± 0.55 | 12.95 ± 1.02 | 17.23 ± 0.55 | 36.87 ± 5.88a,b |
| Creatinine (μM/L) | 28.65 ± 2.54 | 26.80 ± 1.44 | 45.22 ± 2.22 | 66.85 ± 11.22a |
| ALT (U/L) | 22.87 ± 2.11 | 98.88 ± 13.11 | 41.65 ± 7.56 | 257.22 ± 41.98a,b |
The blood creatinine, urea, and ALT levels were analyzed at 18 hrs in mice treated with LPS (2 mg/kg) and at 24 hrs in mice subjected to CLP. The results are presented as mean ± SEM. One-way ANOVA was done followed by Bonferroni post hoc test. aP < 0.05 against the 5/6 nephrectomy group with mentioned treatment. bP < 0.05 against the respective PBS or sham group.