Table 3.

Effect of IKK inhibitor VII on renal dysfunctioning and hepatic injury mediated by sepsis in 5/6 nephrectomized mice.

Parameter	5/6 nephrectomized mice
	5/6 nephrectomized mice (sham) (n = 6)	CLP+vehicle (n = 6)	CLP+IKK inhibitor VII (n = 6)
Urea (mM/L)	16.92 ± 0.75∗	33.45 ± 5.22	22.12 ± 1.25
Creatinine (μM/L)	45.55 ± 2.14	61.58 ± 4.77	51.88 ± 4.66
ALT (U/L)	41.55 ± 6.77∗	221.45 ± 24.55	514.11 ± 35.55

The 5/6 nephrectomized mice were subjected to sham surgery or CLP. After 1-hour CLP, the mice were treated with IKK inhibitor VII or vehicle. The plasma levels of creatinine, urea, and ALT were evaluated after 24 hours post-CLP. ^∗P < 0.05 compared to 5/6 nephrectomized mice + CLP vehicle treated.