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Distinct properties among three types of PARP inhibitors.
| Item | Type I | Type II | Type III |
|---|---|---|---|
| Inhibitors | EB-47, BAD | olaparib, talazoparib | rucaparib, niraparib, veliparib |
| PARP-1 allostery | allosteric | non-allosteric | allosteric |
| HD conformation | destabilization | neutral | more folded |
| PARP-1 affinity for DNA | large increase | small increase | decrease |
| Trapping potency | pro-retention | pro-retention | pro-release |
