Table 2.
Light (LM) and electron microscopic (EM) findings in renal biopsies in 11 patients with HIV and membranous nephropathy
Patient | Diagnoses | Total glomeruli* | GS (%) | IFTA (%) | FSGS | Arteriosclerosis | EM Deposit location | EM MN stage | FPE (%) |
---|---|---|---|---|---|---|---|---|---|
1 | MN | 7 | 0 | < 5 | 0 | Normal/minimal | NA | NA | NA |
2 | HIVAN; MN; mild DN | 42 | 43 | 90 | Collapsing | Severe | Mes; SEpi (segmental); IM | II-III | 60–70 (variable) |
3 | MN; TIN | 38 | 5 | 10 | 0 | Mild | SEpi; IM | II-IV | 100 |
4 | MN; TIN | 39 | 3 | 0 | Moderate | Mes; SEpi; IM | II-III | 50 (variable) | |
5 | MN | 32 | 9 | 5 | 0 | Mild | SEpi | I-II | 100 |
6 | MN | 46 | 42 | 75 | NOS | Severe | SEpi; IM | II-III | 100 |
7 | MN | 25 | 12 | 10 | 0 | Mild | SEpi | I-II | 100 |
8 | MN | 28 | 0 | 5 | 0 | Moderate | SEpi | II | 100 |
9 | MN | 14 | 36 | 50 | 0 | Moderate | SEpi | III | 100 |
10 | MN; LLN | 28 | 0 | 10 | 0 | Mild | Mes (rare); SEndo (rare); SEpi (segmental) | I | 60–70 (variable) |
11 | MN | 45 | 13 | 30 | NOS | Severe | Mes; SEpi | IV | 80% |
Abbreviations: GS: glomerulosclerosis; IFTA: interstitial fibrosis and tubular atrophy; FSGS: focal and segmental glomerulosclerosis; FPE: foot process effacement; MN: membranous nephropathy; TIN: tubulointerstitial nephritis; LLN: lupus-like nephropathy; DN: diabetic nephropathy; Mes.: mesangial; SEpi.: subepithelial (diffuse unless otherwise specified); SEndo.: subendothelial; IM: intramembranous. Deposits are considered diffuse unless otherwise specified. *Describes total glomeruli sampled for LM, EM, and IF