Table 3.
Characteristics and outcomes of pregnant women with confirmed drug-resistant tuberculosis (n=8)
| Participant | Age | TB Presentation | Baseline DST profile | TB treatment regimen | Treatment Outcome |
|---|---|---|---|---|---|
| 1 | 19 |
• Smear +++ pulmonary TB • No history of TB • Cavity seen on CXR • Cough, cough with blood, cough with phlegm, weight loss, difficulty breathing |
MDR (Resistant: INH, RIF, SM) |
CS EMB ETH LEVO PZA |
Treatment completed |
| 2 | 21 |
• Smear + pulmonary TB • History of TB • Cough, cough with phlegm, difficulty breathing, night sweats |
MDR (Resistant: INH, RIF, SM) |
CS EMB ETH LEVO PZA |
Lost to follow up |
| 3 | 29 |
• Smear – pulmonary TB • No history of TB • Cough, cough with blood, cough with phlegm, difficulty breathing, night sweats |
Mono-resistant (Resistant SM) |
EMB INH PZA RIF |
Cured |
| 4 | 30 |
• Smear – pulmonary TB • No history of TB • Cough, cough with blood, cough with phlegm, weight loss, difficulty breathing, night sweats |
Mono-resistant (Resistant: EMB) |
EMB INH PZA RIF |
Cured |
| 5 | 34 |
• Smear ++ pulmonary TB • History of TB • Cough, cough with phlegm, weight loss |
MDR (Resistant: PZA, INH, EMB, RIF, SM) | CS LEVO PAS PZA | Cured |
| 6 | 17 |
• Smear ++ pulmonary TB • No history of TB • History of asthma • Difficulty breathing, night sweats |
Mono-resistant (Resistant: SM) | EMB INH LEVO PZA | Cured |
| 7 | 33 |
• Smear + pulmonary TB • History of TB • Cough, cough with phlegm, weight loss |
Mono-resistant (Resistant: RIF)a |
EMB INH PZA RIF |
Cured |
| 8 | 25 |
• Smear +++ pulmonary TB • No history of TB • Cough, cough with blood, cough with phlegm, weight loss |
MDR (Resistant: INH, EMB, RIF, SM) |
EMB INH PZA RIF |
Treatment completed |
Abbreviations: CXR chest x-ray, CS cycloserine, EMB ethambutol, ETH ethionamide, LEVO levofloxacin, PZA pyrazinamide, INH isoniazid, RIF rifampin, SM streptomycin
aRIF resistance was detected on a second drug susceptible test