Table 3.
Characteristics of Guillain-Barré Syndrome (GBS) patients with antecedent CMV infection (N = 18) and non-CMV infections (N = 107), MarketScan 2009–2015a
| Variable | Persons with GBS and CMV N=18 | Persons with GBS and non-CMV Infections (Campylobacter, Epstein-Barr virus, hepatitis E, influenza, Mycoplasma pneumoniae) N=107 | p-valued | ||
|---|---|---|---|---|---|
| Year | # | % | # | % | |
| 2009 | 2 | 11.1% | 22 | 20.6% | |
| 2010 | 1 | 5.6% | 9 | 8.4% | |
| 2011 | 4 | 22.2% | 17 | 15.9% | |
| 2012 | 4 | 22.2% | 14 | 13.1% | |
| 2013 | 5 | 27.8% | 11 | 10.3% | |
| 2014 | 1 | 5.6% | 15 | 14.0% | |
| 2015 | 1 | 5.6% | 19 | 17.8% | |
| Age group (years) | |||||
| 0–17 | 2 | 11.1% | 21 | 19.6% | |
| 18–34 | 5 | 27.8% | 28 | 26.2% | |
| 35–44 | 5 | 27.8% | 16 | 15.0% | |
| 34–54 | 1 | 5.6% | 13 | 12.1% | |
| 55–64 | 4 | 22.2% | 21 | 19.6% | |
| ≥65 | 1 | 5.6% | 8 | 7.5% | |
| Gender | 1.0000 | ||||
| Female | 10 | 55.6% | 54 | 50.5% | |
| GBS-related proceduresb | |||||
| Lumbar puncture | 15 | 83.3% | 91 | 85.0% | 0.713 |
| EMG or NCS | 13 | 72.2% | 63 | 58.9% | 0.278 |
| GBS Severity/Outcomes | |||||
| Dysautonomiac | 1 | 5.6% | 3 | 2.8% | 1.000 |
| ICU Hospitlization | 9 | 50.0% | 58 | 54.2% | 0.793 |
| Intubation | 5 | 27.8% | 17 | 15.9% | 0.473 |
| Died | 1 | 5.6% | 0 | 0.0% | 0.130 |
| Median Duration of Hospitalization (range), in days | 7 (1–38 days) | 7 (0–34 days) | 0.811 | ||
There were a total of 125 GBS cases with an antecedent infection with a specific pathogen identified. Two of the 125 GBS cases had claims for both CMV and EBV and are included in the frequencies of persons with GBS and CMV.
GBS-related procedures that occurred within −45 to 45 days of GBS onset date.
Proportion of persons with dysautonomia among persons enrolled over the 14-month interval ranging from 2 months before through 12 months after GBS onset date (N = 2,105, 180 in persons aged <18 years and 1,925 in persons aged ≥18 years).
Statistical analysis excludes the 2 GBS cases with both CMV and EBV from the comparison of GBS patients with and without CMV.