Skip to main content
. Author manuscript; available in PMC: 2020 Sep 19.
Published in final edited form as: Curr Biol. 2019 May 23;29(11):1787–1799.e5. doi: 10.1016/j.cub.2019.04.072

Figure 7. Model of Mechanism of Cold-Temperature Adaptation.

Figure 7.

TRPM8 activation at cold temperature results in an increase in Ca2+ spike frequency in developing spinal cord neurons. This enhanced spike frequency increases HB9-dependent motor neuron differentiation and survival. The low-temperature mediated increase in motor neuron number facilitates faster escape swimming at cold temperature compared to animals grown in warm temperature, for efficiently evading predators and increasing rate of survivability.