Fig. 5. Conformational changes at interprotomer contact sites along the augmented functional path.

The monomers are shown in different colors. Red markers highlight known point-mutations involved in malignant hyperthermia-1 and central core disease of muscle. Distance variations are between two amino acid backbones at contact sites between the monomers. The amino acids used for measurement are shown as sticks. Distance variations between carbon-alpha backbone atoms of two opposing residues along the augmented functional path. Error bars represent the full scatter (not standard deviation) of the results obtained with six different starting models.