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. Author manuscript; available in PMC: 2020 Sep 20.
Published in final edited form as: Am J Med Genet A. 2020 Mar 3;182(5):1143–1151. doi: 10.1002/ajmg.a.61539

Figure 3. Fluorescent in situ hybridization (FISH) localizes paternally-inherited duplication of chromosome 1p31.2 to chromosome 22.

Figure 3.

(A) Chromosomes from the proband (left panels) and father (right panels) were hybridized with a probe targeting telomere 1q (green fluorescent label) and a probe targeting the paternal duplication originating from 1p31.2 (red fluorescent label). A third signal of the 1p31.2 probe can be seen on one of the smaller chromosomes (red arrow). (B) Utilizing probes targeting 1p31.2 (red) and chromosome 22 (telomere 22q, green), the duplication was localized to chromosome 22 (red arrow) in both the proband and his father.