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Hsp90 inhibitors derived from natural products – A) Geldanamycin is a benzoquinone ansamycin antibiotic. Three of its derivatives (tanespimycin, IPI-493, and alvespimycin) make substitutions to the C-17 position. B) In addition to a C-17 substitution, retaspimycin is the reduced derivative of GDA. C) Radicicol is an antifungal natural product.
