Table 3.
Leukocyte counts, leukocyte proportions and CRP concentration by population and reproductive status
| Measure | Population | Cycling | Trimester 1 | Trimester 2 | Trimester 3 |
|---|---|---|---|---|---|
| Total leukocytes (cells/µl) | NHANES | 7013 (4473, 10 885) | 8154 (5172, 12 769) | 9132 (5833, 14 450) | 9056 (5825, 14 338) |
| THLHP | 9392 (6112, 14 788) | 9733 (6311, 15 432) | 9248 (6015, 14 644) | 9109 (5869, 14 353) | |
| Δ | 2439 (2182, 2690) | 1661 (894, 2408) | 135 (−441, 755) | 44 (−563, 627) | |
| 34.8% (30.8%, 38.6%) | 20.5% (10.6%, 31.1%) | 1.5% (−4.7%, 8.4%) | 0.5% (−6.0%, 7.1%) | ||
| Neutrophils (cells/µl) | NHANES | 3914 (2156, 7080) | 5158 (2886, 9356) | 6602 (3736, 11 741) | 6439 (3593, 11 821) |
| THLHP | 4866 (2728, 8556) | 5265 (2946, 9432) | 5762 (3191, 10 029) | 5855 (3248, 10 507) | |
| Δ | 872 (704, 1049) | 83 (−488, 673) | −758 (−1289, −260) | −652 (−1170, −107) | |
| 22.0% (17.5%, 26.8%) | 1.6% (−8.8%, 14.0%) | −11.6% (−19.0%, −4.1%) | −10.1% (−17.4%, −1.7%) | ||
| Lymphocytes (cells/µl) | NHANES | 2178 (1313, 3606) | 1980 (1184, 3282) | 1836 (1080, 3092) | 1704 (1020, 2900) |
| THLHP | 2768 (1678, 4603) | 2694 (1599, 4501) | 2159 (1290, 3600) | 2169 (1296, 3727) | |
| Δ | 568 (479, 659) | 715 (489, 935) | 324 (165, 486) | 480 (329, 637) | |
| 26.1% (21.8%, 30.5%) | 36.5% (23.7%, 49.8%) | 17.7% (8.6%, 27.3%) | 28.5% (18.9%, 38.8%) | ||
| Eosinophils (cells/µl) | NHANES | 125 (10, 520) | 133 (11, 535) | 106 (9, 447) | 104 (10, 419) |
| THLHP | 1176 (249, 5669) | 1315 (281, 5909) | 947 (196, 4268) | 695 (152, 3200) | |
| Δ | 1016 (914, 1139) | 1095 (856, 1404) | 784 (629, 973) | 553 (432, 703) | |
| 555.1% (490.9%, 630.7%) | 572.9% (400.7%, 826.9%) | 514.3% (388.5%, 680.4%) | 379.3% (272.3%, 515.4%) | ||
| Monocytes (cells/µl) | NHANES | 493 (287, 837) | 537 (323, 918) | 550 (319, 936) | 609 (355, 1020) |
| THLHP | 0 (0, 136) | 0 (0, 168) | 0 (0, 92) | 0 (0, 126) | |
| Δ | −457 (−814, −224) | −494 (−892, −235) | −516 (−900, −287) | −577 (−981, −299) | |
| Basophils (cells/µl) | NHANES | 0 (0, 113) | 0 (0, 114) | 0 (0, 118) | 0 (0, 112) |
| THLHP | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| Δ | 0 (−113, 0) | 0 (−114, 0) | 0 (−114, 0) | 0 (−112, 0) | |
| % Neutrophil | NHANES | 56.4% (41.9%, 76.7%) | 63.9% (47.6%, 84.9%) | 71.0% (52.7%, 93.9%) | 71.8% (53.6%, 95.6%) |
| THLHP | 51.1% (38.0%, 68.9%) | 53.9% (40.4%, 72.4%) | 61.8% (45.7%, 82.6%) | 64.4% (47.7%, 86.5%) | |
| Δ | −5.2% (−6.3%, −4.1%) | −9.8% (−13.3%, −6.7%) | −9.2% (−12.1%, −6.4%) | −7.3% (−10.3%, −4.2%) | |
| % Lymphocytes | NHANES | 30.7% (20.1%, 47.4%) | 24.4% (15.9%, 36.5%) | 19.6% (12.7%, 30.8%) | 18.6% (12.3%, 29.1%) |
| THLHP | 28.8% (19.2%, 43.9%) | 27.3% (17.5%, 41.8%) | 23.3% (15.0%, 35.8%) | 23.6% (15.2%, 36.8%) | |
| Δ | −2.0% (−2.9%, −1.1%) | 3.1% (0.9%, 5.3%) | 3.2% (1.8%, 4.7%) | 5.2% (3.8%, 6.7%) | |
| % Eosinophils | NHANES | 3.2% (1.2%, 7.1%) | 2.8% (1.1%, 6.2%) | 2.4% (0.9%, 5.4%) | 2.3% (0.9%, 5.4%) |
| THLHP | 15.1% (5.7%, 33.3%) | 14.5% (5.4%, 32.7%) | 11.8% (4.4%, 26.5%) | 9.5% (3.5%, 20.8%) | |
| Δ | 11.5% (10.8%, 12.2%) | 11.2% (9.7%, 12.8%) | 9.0% (8.0%, 10.2%) | 6.8% (5.9%, 7.7%) | |
| % Monocytes | NHANES | 7.5% (4.9%, 11.6%) | 7.2% (4.6%, 11.2%) | 6.4% (4.1%, 9.9%) | 7.2% (4.7%, 11.2%) |
| THLHP | 0.0% (0.0%, 2.0%) | 0.0% (0.0%, 2.0%) | 0.0% (0.0%, 2.0%) | 0.0% (0.0%, 2.0%) | |
| Δ | −7.2% (−11.3%, −4.2%) | −6.9% (−10.9%, −3.9%) | −6.9% (−11.0%, −4.1%) | −6.9% (−11.1%, −4.0%) | |
| % Basophils | NHANES | 0.0% (0.0%, 2.0%) | 0.0% (0.0%, 1.0%) | 0.0% (0.0%, 1.0%) | 0.0% (0.0%, 1.0%) |
| THLHP | 0.0% (0.0%, 0.0%) | 0.0% (0.0%, 0.0%) | 0.0% (0.0%, 0.0%) | 0.0% (0.0%, 0.0%) | |
| Δ | 0.0% (−2.0%, 0.0%) | 0.0% (−1.0%, 0.0%) | 0.0% (−1.0%, 0.0%) | 0.0% (−1.0%, 0.0%) | |
| CRP (mg/l) | NHANES | 1.48 (0.25, 8.08) | 4.03 (0.70, 23.57) | 5.04 (0.87, 30.26) | 3.47 (0.59, 21.19) |
| THLHP | 1.32 (0.24, 7.64) | 3.92 (0.60, 24.56) | 3.91 (0.65, 24.68) | 1.67 (0.24, 9.68) | |
| Δ | −0.13 (−0.51, 0.40) | −0.11 (−2.30, 3.34) | −1.04 (−3.00, 2.25) | −1.89 (−2.85, −0.25) | |
| −8.4% (−33.1%, 27.4%) | −2.8% (−52.7%, 91.7%) | −20.2% (−56.0%, 46.2%) | −54.1% (−75.8%, −6.7%) |
For all measures, reported absolute values are the estimated median, 5th and 95th percentiles of the posterior population distributions, standardized by age, BMI and parity. Estimated median, 5th and 95th percentiles for delta values (Δ) represent the calculated difference between standardized parameter distributions, with the exception of monocytes and basophils, which were calculated using the difference between posterior population distributions to include excess zero values (and therefore produce larger confidence intervals).