. Author manuscript; available in PMC: 2021 Feb 3.

Published in final edited form as: Angew Chem Int Ed Engl. 2019 Dec 20;59(6):2414–2419. doi: 10.1002/anie.201912273

Table 2.

Relaxivity values for Fe(L1), Fe(L2), Fe(L3), and Fe(L4) measured at 4.7T, pH 7.2 and 37°C compared to Gd(DTPA).

Complex	r₁ (mM⁻¹sec⁻¹)	r₂ (mM⁻¹sec⁻¹)	r₁ (mM⁻¹sec⁻¹) in HSA	r₂ (mM⁻¹sec⁻¹) in HSA	r₁ (mM⁻¹sec⁻¹) in serum	r₂ (mM⁻¹sec⁻¹) in serum
Fe(L1)	2.2 ± 0.3	4.5 ± 1.1	2.5 ± 0.1	4.2 ± 0.7	3.8 ± 0.38	6.2 ± 0.62
Fe(L2)	0.81 ± 0.07	1.5 ± 0.1	1.1 ± 0.02	1.6 ± 0.04	-	-
Fe(L3)	1.7 ± 0.1	5.0 ± 0.5	2.2 ± 0.01	3.6 ± 0.2	1.8 ± 0.18	3.0 ± 0.30
Fe(L4)	0.42 ± 0.2	1.5 ± 0.05	0.96 ± 0.02	2.0 ± 0.2	-	-
Gd(DTPA)	3.1 ± 0.31	3.9 ± 0.39	3.2 ± 0.32	4.0 ± 0.40	4.1 ± 0.41	5.0 ± 0.50