Table 1.

Naranjo algorithm of the patient showing score 7 (probable drug induced dystonic reaction) on day 2 of bupropion administration

Questions	Yes	No	Do not know	Score
1. Are there any previous conclusive reports on this reaction?	+1	0	0	+1
2. Did the adverse event appear after the suspected drug was administered?	+2	-1	0	+2
3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?	+1	0	0	+1
4. Did the adverse reaction reappear when the drug was readministered?	+2	-1	0	0
5. Are there alternative causes (other than the drug) that could on their own have caused the reaction?	-1	+2	0	+2
6. Did the reaction reappear when placebo was given?	-1	+1	0	+1
7. Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?	+1	0	0	0
8. Was the reaction more severe when the dose was increased or less severe when dose was decreased?	+1	0	0	0
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	+1	0	0	0
10. Was the adverse event confirmed by any objective evidence?	+1	0	0	0
Total*				7

^*the adverse drug reaction is assigned to a probability category from the total score as follows: definite, > 8; probable, 5–8; possible, 1–4; doubtful, < 1.