Table 4.
Biochemistry.
| Parameters | CCHD patients | Control | p-value |
|---|---|---|---|
| Haematocrit (%), median (IQR) | 0.58 (0.53–0.63) | 0.42 (0.38–0.44) | <0.0001 |
| Haemoglobin (mmol/L), median (IQR) | 12.0 (11.1–12.9) | 8.7 (8.2–9.2) | <0.0001 |
| Platelets (×109/L), mean (±SD) | 171.0 (±55.9) | 241.3 (±52.9) | <0.0001 |
| CRP (mg/L), median [p25-p75] | 2.9 [1.0–5.5] | 1.0 [1.0–2.5] | 0.02 |
| Leukocytes (×109/L), mean (±SD) | 6.77 (±1.56) | 6.02 (±1.90) | 0.04 |
| Neutrophils (×109/L), mean (±SD) | 4.41(±1.23) | 3.65 (±1.64) | 0.01 |
| Creatinine (µmol/L), mean (±SD) | 80.5(±23.5) | 77.4 (±14.1) | 0.5 |
| ProBNP (pmol/L), mean (±SD) | 104.9 (±134.7) | 6.6 (±8.9) | <0.0001 |
| Total cholesterol (mmol/L), mean (±SD) | 4.91 (±1.16) | 5.29 (±0.90) | 0.1 |
| LDL cholesterol (mmol/L), mean (±SD) | 3.03 (±1.01) | 3.2 (±0.78) | 0.4 |
| HDL cholesterol (mmol/L), mean (±SD) | 1.36 (±0.47) | 1.76 (±0.45) | 0.0003 |
| Triglycerides (mmol/L), median [IQR] | 1.38 [0.85–2.03] | 1.0 [0.72–1.44] | 0.02 |
| Hb1AC (mmol/mol), mean (±SD) | 37.7 (±3.9) | 34.2 (±3.8) | 0.0001 |
| Homocysteine (µmol/L), mean (±SD) | 18.3 (±6.7) | 12.6 (±4.6) | <0.0001 |
| HsCRP (mg/L), median [IQR] | 2.25 [1.0–4.7] | 1.0 [0.6–2.0] | 0.02 |
| ApoM (µmol/L), mean (±SD) | 1.00 (±0.59) | 1.39 (±0.51) | 0.02 |
| S1P (µmol/L), mean (±SD) | 0.74 (±0.48) | 0.51(±0.18) | 0.04 |
| Albuminuria, % (n) | 42 (19) | 7 (3) | 0.0001 |
CCHD = cyanotic congenital heart disease, IQR: interquartile range, SD = standard deviation, LDL = low density lipoprotein, HDL = high density lipoprotein, HbA1C = haemoglobin A1C, apoM = apolipoprotein M, S1P = sphingosine-1-phosphate.